In a review with PlayStation Magazine, Hideo Kojima confirms that they will have to make Metal gear Solid 5 at some point in the future, but they have no idea when or what the vision might be for this game.

What is interesting is that in the article Kojima provides no assurance that he will be directing it or even be involved in it. Kojima Production staff might be turned loose on the development of the 5th installment, as the man himself tried to get out from under working on the franchise so that he can work on other things.